pI: 7.8103 |
Length (AA): 429 |
MW (Da): 47004 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 422 | 1ps9 (A) | 4 | 391 | 18.00 | 0 | 1 | 1.03335 | 0.49 |
14 | 344 | 1vyr (A) | 15 | 326 | 29.00 | 0.0011 | 1 | 0.861062 | 0.2 |
149 | 353 | 3oa3 (A) | 66 | 251 | 11.00 | 0 | 0.59 | 0.489855 | -0.22 |
156 | 211 | 4qnw (A) | 123 | 180 | 32.00 | 0.62 | 0.54 | 0.341036 | 0.83 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127243)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G09400 | putative 12-oxophytodienoate reductase-like protein 1 |
Candida albicans | CaO19.3131 | potential NADH-dependent flavin oxidoreductase |
Candida albicans | CaO19.10643 | potential NADH-dependent flavin oxidoreductase |
Caenorhabditis elegans | CELE_W06H8.2 | Protein W06H8.2 |
Dictyostelium discoideum | DDB_G0286923 | NADH:flavin oxidoreductase/NADH oxidase domain-containing protein |
Dictyostelium discoideum | DDB_G0293114 | NADH:flavin oxidoreductase/NADH oxidase domain-containing protein |
Dictyostelium discoideum | DDB_G0287765 | NADH:flavin oxidoreductase/NADH oxidase domain-containing protein |
Dictyostelium discoideum | DDB_G0271752 | NADH:flavin oxidoreductase/NADH oxidase domain-containing protein |
Dictyostelium discoideum | DDB_G0277969 | NADH:flavin oxidoreductase/NADH oxidase domain-containing protein |
Dictyostelium discoideum | DDB_G0287561 | NADH:flavin oxidoreductase/NADH oxidase domain-containing protein |
Dictyostelium discoideum | DDB_G0279473 | NADH:flavin oxidoreductase/NADH oxidase domain-containing protein |
Escherichia coli | b3081 | 2,4-dienoyl-CoA reductase, NADH and FMN-linked |
Giardia lamblia | GL50803_9719 | NADH oxidase |
Leishmania braziliensis | LbrM.33.1020 | 2,4-dienoyl-coa reductase fadh1, putative |
Leishmania braziliensis | LbrM.06.0910 | 2,4-dienoyl-coa reductase-like protein |
Leishmania donovani | LdBPK_330870.1 | 2,4-dienoyl-coa reductase fadh1, putative |
Leishmania donovani | LdBPK_060960.1 | 2,4-dienoyl-coa reductase-like protein |
Leishmania infantum | LinJ.06.0960 | 2,4-dienoyl-coa reductase-like protein |
Leishmania infantum | LinJ.33.0870 | 2,4-dienoyl-coa reductase fadh1, putative |
Leishmania major | LmjF.06.0930 | 2,4-dienoyl-coa reductase-like protein |
Leishmania major | LmjF.33.0830 | 2,4-dienoyl-coa reductase fadh1, putative |
Leishmania mexicana | LmxM.32.0830 | 2,4-dienoyl-coa reductase fadh1, putative |
Leishmania mexicana | LmxM.06.0930 | 2,4-dienoyl-coa reductase-like protein |
Mycobacterium tuberculosis | Rv1175c | Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) |
Mycobacterium ulcerans | MUL_0469 | hypothetical protein |
Mycobacterium ulcerans | MUL_1023 | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
Trypanosoma brucei gambiense | Tbg972.7.6430 | 2,4-dienoyl-coa reductase-like protein |
Trypanosoma brucei | Tb927.7.5540 | 2,4-dienoyl-coa reductase-like protein |
Trypanosoma congolense | TcIL3000_7_4560 | 2,4-dienoyl-coa reductase-like protein, putative |
Trypanosoma cruzi | TcCLB.509941.100 | 2,4-dienoyl-coa reductase fadh1, putative |
Trypanosoma cruzi | TcCLB.510303.210 | 2,4-dienoyl-coa reductase-like protein, putative |
Trichomonas vaginalis | TVAG_220000 | NADPH dehydrogenase, putative |
Trichomonas vaginalis | TVAG_152690 | N-ethylmaleimide reductase, putative |
Trichomonas vaginalis | TVAG_443770 | N-ethylmaleimide reductase, putative |
Trichomonas vaginalis | TVAG_405820 | NADH:flavin oxidoreductase, putative |
Trichomonas vaginalis | TVAG_351540 | 2,4-dienoyl-CoA reductase [NADPH], putative |
Trichomonas vaginalis | TVAG_478830 | N-ethylmaleimide reductase, putative |
Trichomonas vaginalis | TVAG_411220 | N-ethylmaleimide reductase, putative |
Trichomonas vaginalis | TVAG_510340 | N-ethylmaleimide reductase, putative |
Trichomonas vaginalis | TVAG_093680 | 2,4-dienoyl-CoA reductase [NADPH], putative |
Trichomonas vaginalis | TVAG_272880 | NADH oxidase, putative |
Trichomonas vaginalis | TVAG_399520 | 2,4-dienoyl-CoA reductase [NADPH], putative |
Trichomonas vaginalis | TVAG_127520 | N-ethylmaleimide reductase, putative |
Trichomonas vaginalis | TVAG_121620 | N-ethylmaleimide reductase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1196 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.7.5540 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.5540 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.5540 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.5540 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3081 | Escherichia coli | non-essential | goodall |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.